Dr. A Mukherjee's Lab
Embedded Files
Our research integrates fundamental and translational approaches to investigate the molecular basis of virus-host interactions - defining the factors essential for viral replication and the pathogenic pathways activated by viral proteins - to guide the strategic advancement of diagnostic technologies and biologic therapeutics.
PRINCIPAL INVESTIGATOR
Dr. Anupam Mukherjee
Dr. Anupam Mukherjee
SCIENTIST - E & ASSOCIATE PROFESSOR
ICMR - National Institute of Virology
Metrices
Citations 11935 | h-index 26 | i10-index 42
Dr. AM's profile
Dr. Anupam Mukherjee completed his M.Sc. in Zoology from the University of Calcutta and earned his Ph.D. in Life Sciences/Virology from Jadavpur University. His doctoral research, conducted at ICMR-NICED, Kolkata, focused heavily on the genomic analysis and surveillance of human Rotavirus strains and included involvement in pandemic Influenza studies. Following his Ph.D., his postdoctoral training included work on Rotavirus pathogenesis before he moved to the Department of Pathology, Saint Louis University, USA. There, he conducted NIH-funded research that was crucial for revealing the role of cellular microRNAs in HCV pathogenesis, specifically identifying mechanisms that link viral infection to the suppression of interferon signaling and the progression toward liver cancer.
Key areas of research
Characterization of virus-host interactions concerning viral replication and pathogenesis, focusing on the identification of pathogenic mechanisms triggered by viral proteins. This includes investigating transcriptional dysregulation during HSV-2 infection and elucidating the miRNA-mediated Interferon modulations during early HSV-2 infection.
Developing RNA interference (RNAi), specifically miRNA or siRNA, as a potential therapeutic strategy against HIV and HIV-associated opportunistic viruses (HSV, HCV, HPV, or MPXV). This includes the development of an mRNA vaccine strategy specifically against HSV-2.
Utilizing targeted delivery systems through tagging with nanoparticles to deliver potential antivirals. The lab currently leads projects investigating miRNA Loaded Nanoparticles as an antiviral approach against HSV-2 pathogenesis.
Ongoing projects in the lab focus on delineating the regulatory roles of microRNAs in HIV/HCV co-infection and HPV-driven oncogenesis, uncovering transcriptional dysregulation mechanisms during HSV-2 infection, and advancing the development of an mRNA vaccine targeting HSV-2.
Step Inside the Lab
Our Core Question
What dictates the outcome of a viral infection at the molecular level, and how can we rationally intervene?
Research Areas
Molecular Virology and Infectious Diseases, Virus-Host Interaction and Molecular Pathogenesis, Antiviral Drug Discovery and Biological Medicines
Dr. Anupam Mukherjee’s research in Molecular Virology focuses on uncovering how major human viruses subvert host defenses. His pioneering work on Hepatitis C Virus (HCV) revealed how the virus manipulates the host microRNA system to promote its persistence and drive liver disease, establishing a foundation in molecular pathogenesis and host gene regulation.
Currently, his lab pursues two core goals: dissecting virus–host immune crosstalk to identify key regulatory nodes, and translating these insights into targeted antiviral strategies. Emphasizing RNA interference (RNAi)-based approaches, the group aims to generate fundamental molecular knowledge that informs the development of next-generation diagnostics and precision therapeutics.
Meet the minds behind the research
Mr. Harshithkumar R
Mr. Harshithkumar R
UGC - Senior Research Fellow
Hometown: Karnataka, India
Research domain
Molecular Virology of HIV-1: microRNA Regulation, Oxidative Stress, and Antiviral Therapeutics
My primary research domain lies in HIV-1 molecular virology, with a strong emphasis on deciphering the intricate virus–host interactions, redox imbalance, and microRNA-mediated regulatory mechanisms that shape viral replication and persistence. I aim to understand how these molecular processes influence disease progression and immune modulation during HIV-1 infection. Complementary studies extend to HPV and HSV, addressing viral pathogenesis and therapeutic design through RNA-based and nanomaterial-driven interventions.
Ms. Debashree Dass
Ms. Debashree Dass
CSIR - Senior Research Fellow
Hometown: West Bengal, India
Research domain
Molecular Virology; microRNA therapeutics; Nanomedicine
My research focuses on developing innovative antiviral strategies against Herpes Simplex Virus type 2 (HSV-2) using microRNA-based therapeutics. I investigate how cellular microRNAs regulate viral pathogenesis and immune responses, particularly inflammasome activation and autophagy modulation. My work bridges molecular virology, immunology, and nanotechnology to create novel therapeutic strategies against viral infections, with potential applications in treating sexually transmitted infections and advancing antiviral drug development.
Mr. Suneesh N S
Mr. Suneesh N S
ICMR-AcSIR - Junior Research Fellow
Hometown: Kerala, India
Research domain
HSV-2; Molecular Virology; mRNA Vaccine; Transcriptomics; Viral Immunology; Systems biology
My research centers on Herpes Simplex Virus type 2 (HSV-2) and integrates multiple complementary approaches to advance our understanding and control of this pathogen. This includes the design and engineering of multivalent, multiepitope mRNA vaccine candidates targeting key viral antigens, complemented by comprehensive transcriptomic, systems biology, and mechanistic studies to delineate the complex interplay between host and viral factors and to identify the molecular pathways that govern HSV-2 infection, latency, and pathogenesis.
Ms. Ishrat Khan
Ms. Ishrat Khan
DHR-ICMR - Woman Scientist
Hometown: Rajasthan, India
Research domain
HPV; Molecular Virology; Virus–Host Interaction; miRNA Dysregulation; Oncogenesis
I investigate the molecular mechanisms underlying Human Papillomavirus (HPV)-driven cervical cancer, focusing on virus–host interactions and microRNA-mediated regulation. My research explores how HPV infection modulates immune responses and cellular signaling pathways, contributing to cancer initiation and progression. Through an integrative approach combining molecular virology, immunology, and miRNA biology, I aim to uncover mechanistic insights into viral oncogenesis and discover potential therapeutic targets.
Mrs. Madhuri Chandane-Tak
Mrs. Madhuri Chandane-Tak
ICMR - Technical Officer - C & Ph.D. scholar
Hometown: Maharashtra, India
HIV/HCV coinfection; HCC; microRNAs; virus–host interactions; systems biology; biomarkers; therapeutics
HIV/HCV
My area of research is on HIV/HCV coinfection and its progression to chronic liver diseases, including fibrosis and hepatocellular carcinoma (HCC). I study how viral coinfection alters host immune responses and cellular pathways, with a particular focus on the regulatory role of microRNAs. I aim to uncover molecular networks driving disease progression and identify biomarkers and therapeutic targets for precision management of HIV/HCV-associated liver disease.
Our Alumni
Mr. Kishore Dhotre
Mr. Kishore Dhotre
Doctoral Research Fellow
Friedrich-Alexander University of Erlangen-Nürnberg, Germany
Page updated
Google Sites
Report abuse